{"id":290,"date":"2016-04-15T15:14:32","date_gmt":"2016-04-15T15:14:32","guid":{"rendered":"https:\/\/jilab.fi\/?page_id=290"},"modified":"2026-03-18T15:16:03","modified_gmt":"2026-03-18T13:16:03","slug":"pathology-contract-services-celiac-etc","status":"publish","type":"page","link":"https:\/\/jilab.fi\/index.php\/pathology-contract-services-celiac-etc\/","title":{"rendered":"Pathology Contract Services for Celiac Disease Drug Trials"},"content":{"rendered":"\n<p style=\"font-size:clamp(14px, 0.875rem + ((1vw - 3.2px) * 0.526), 18px);\">Jilab Inc. has a modern histopathology laboratory, which is specialized in providing services for academic research and for pharma industry.<\/p>\n\n\n\n<p style=\"font-size:clamp(14px, 0.875rem + ((1vw - 3.2px) * 0.526), 18px);\">Jilab offers histotechnical services, including tissue processing, sectioning, staining, immunohistochemistry, whole slide imaging, quantitative image analysis and reporting. Additionally, Jilab offers RNA extraction and RNAseq services. The laboratory is run by Prof. Jorma Isola, (MD, PhD), who is board-certified pathologist with 30-year experience in histopathology.<\/p>\n\n\n\n<p style=\"font-size:clamp(14px, 0.875rem + ((1vw - 3.2px) * 0.526), 18px);\">Jilab has developed digital quantitative morphometry tools for celiac disease biopsy pathology, including morphometric methods for analyzing duodenal villus atrophy, crypt hyperplasia, and inflammation.<\/p>\n\n\n\n<p style=\"font-size:clamp(14px, 0.875rem + ((1vw - 3.2px) * 0.526), 18px);\">Jilab laboratory is a CLIA certified laboratory.<\/p>\n\n\n\n<p style=\"font-size:clamp(14px, 0.875rem + ((1vw - 3.2px) * 0.526), 18px);\">Our IT systems have undergone quality inspection by CyberVadis Inc. earning a bronze medal that highlights a solid level of cybersecurity awareness and implementation. <br><br>Jilab Oy\u00a0is testing laboratory No. T360 accredited by FINAS Finnish Accreditation Service, accreditation requirement SFS-EN ISO\/IEC 15189.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"663\" src=\"https:\/\/jilab.fi\/wp-content\/uploads\/2026\/03\/finas-1024x663.png\" alt=\"Finas\" class=\"wp-image-956\" style=\"width:150px\" srcset=\"https:\/\/jilab.fi\/wp-content\/uploads\/2026\/03\/finas-1024x663.png 1024w, https:\/\/jilab.fi\/wp-content\/uploads\/2026\/03\/finas-300x194.png 300w, https:\/\/jilab.fi\/wp-content\/uploads\/2026\/03\/finas-768x498.png 768w, https:\/\/jilab.fi\/wp-content\/uploads\/2026\/03\/finas-1536x995.png 1536w, https:\/\/jilab.fi\/wp-content\/uploads\/2026\/03\/finas.png 1690w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" style=\"margin-top:var(--wp--preset--spacing--50);margin-bottom:var(--wp--preset--spacing--50)\"\/>\n\n\n\n<h2 class=\"wp-block-heading is-style-default has-open-sans-font-family\" style=\"font-size:clamp(14px, 0.875rem + ((1vw - 3.2px) * 0.526), 18px);\"><strong>VH\/CD and IEL counting using proprietary image analysis software<\/strong><\/h2>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-top is-layout-flex wp-container-core-columns-is-layout-0884d4d2 wp-block-columns-is-layout-flex\" style=\"margin-top:var(--wp--preset--spacing--50);margin-bottom:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<p style=\"font-size:14px\">Celiac disease Histology (H&amp;E):<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69d587dcc48b3&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69d587dcc48b3\" class=\"wp-block-image size-full wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"978\" height=\"769\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/Celiac-disease-HE.png\" alt=\"Celiac-disease-H&amp;E\" class=\"wp-image-925\" srcset=\"https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/Celiac-disease-HE.png 978w, https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/Celiac-disease-HE-300x236.png 300w, https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/Celiac-disease-HE-768x604.png 768w\" sizes=\"auto, (max-width: 978px) 100vw, 978px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<p style=\"font-size:14px\">Normal mucosal&nbsp;biopsy Histology (H&amp;E):<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69d587dcc4f6a&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69d587dcc4f6a\" class=\"wp-block-image size-full wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"616\" height=\"718\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/Normal-HE.png\" alt=\"Normal-H&amp;E\" class=\"wp-image-923\" srcset=\"https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/Normal-HE.png 616w, https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/Normal-HE-257x300.png 257w\" sizes=\"auto, (max-width: 616px) 100vw, 616px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<p style=\"font-size:14px\">Intraepithelial lymphocyte count on CD3-IHC staining<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69d587dcc553d&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69d587dcc553d\" class=\"wp-block-image size-full wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1431\" height=\"889\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/Auto-IEL.png\" alt=\"Auto-IEL\" class=\"wp-image-922\" srcset=\"https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/Auto-IEL.png 1431w, https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/Auto-IEL-300x186.png 300w, https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/Auto-IEL-1024x636.png 1024w, https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/Auto-IEL-768x477.png 768w\" sizes=\"auto, (max-width: 1431px) 100vw, 1431px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<p style=\"font-size:14px\">Villus height : Crypt depth measurement<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69d587dcc5b28&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69d587dcc5b28\" class=\"wp-block-image size-full wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"986\" height=\"972\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/VHCD-tool.png\" alt=\"VHCD-tool\" class=\"wp-image-921\" srcset=\"https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/VHCD-tool.png 986w, https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/VHCD-tool-300x296.png 300w, https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/VHCD-tool-768x757.png 768w\" sizes=\"auto, (max-width: 986px) 100vw, 986px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-0884d4d2 wp-block-columns-is-layout-flex\" style=\"margin-top:var(--wp--preset--spacing--50);margin-bottom:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p style=\"font-size:14px\">VHCD digital image analysis<\/p>\n\n\n\n<figure class=\"wp-block-video\"><video height=\"1000\" style=\"aspect-ratio: 1406 \/ 1000;\" width=\"1406\" controls src=\"https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/vhcdu3.mp4\"><\/video><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p style=\"font-size:14px\">IEL digital image analysis<\/p>\n\n\n\n<figure class=\"wp-block-video\"><video height=\"1000\" style=\"aspect-ratio: 1406 \/ 1000;\" width=\"1406\" controls src=\"https:\/\/jilab.fi\/wp-content\/uploads\/2026\/01\/IEL-digital-image-analysis.mp4\"><\/video><\/figure>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" style=\"margin-top:var(--wp--preset--spacing--50);margin-bottom:var(--wp--preset--spacing--50)\"\/>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<p><strong>References:<\/strong><\/p>\n\n\n\n<p>Cellier C et al. Safety and efficacy of AMG 714 in patients with type 2 refractory coeliac disease: a phase 2a, randomised, double-blind, placebo-controlled, parallel-group study. Lancet Gastroenterol Hepatol 2019 Dec;4(12):960-970. doi: 10.1016\/S2468-1253(19)30265-1. Epub 2019 Sep 4.<\/p>\n\n\n\n<p><b><\/b>Daveson A, Popp A, Taavela J, Goldstein K, Isola J, Truitt K, M\u00e4ki M, Anderson RP, on behalf of&nbsp;the RESET CeD Study Group. Baseline quantitative histology in therapeutics trials reveals villus atrophy in most patients with coeliac disease who appear well controlled on gluten\u2010free diet GastroHep https:\/\/doi.org\/10.1002\/ygh2.380. First published: 17 November 2019<\/p>\n\n\n\n<p>Dotsenko V, Oittinen M, Taavela J, Popp A, Per\u00e4aho M, Staff S, Sarin J, Leon F, Isola J, M\u00e4ki M, Viiri K. Genome-wide transcriptomic analysis of intestinal mucose in celiac disease patients on a gluten-free diet and post gluten challenge. Cell Mol Gastroenterol Hepatol.Cell Mol Gastroenterol Hepatol. 2021;11(1):13-32. doi: 10.1016\/j.jcmgh.2020.07.010. Epub 2020 Jul 31.<\/p>\n\n\n\n<p>Lamacchia C et al. Healthy and pro-inflammatory gut ecology plays a crucial role in the digestion and tolerance of a novel Gluten Friendly\u2122 bread in celiac subjects: a randomized, double blind, placebo control in vivo study. Food &amp; Function&nbsp; 2022 Feb 7;13(3):1299-1315. doi: 10.1039\/d1fo00490e.2022<\/p>\n\n\n\n<p>L\u00e4hdeaho ML, Scheinin M, Vuotikka P, Taavela J, Popp A, Laukkarinen J, Koffert J, Koivurova OP, Pesu M, Kivel\u00e4 L, Lovr\u00f3 Z, Keisala J, Isola J, Parnes JR, Leon F, M\u00e4ki M. Safety and efficacy of AMG 714 in adults with coeliac disease exposed to gluten challenge: a phase 2a, randomised, double-blind, placebo-controlled study. Lancet Gastroenterol Hepatol. 2019 Dec;4(12):948-959. Epub 2019 Sep 4.<\/p>\n\n\n\n<p>Popp A, Taavela J, Anderson B, Isola J, M\u00e4ki M. Small intestine digital histomorphometry for celiac disease. Popp A et al. DDW 2016 Congress abstract &amp; poster presentation.<\/p>\n\n\n\n<p>Schuppan D et al. A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease. N Engl J Med. 2021 Jul 1;385(1):35-45. doi: 10.1056\/NEJMoa2032441.<\/p>\n\n\n\n<p>Taavela J, Koskinen O, Huhtala H, L\u00e4hdeaho ML, Popp A, Laurila K, Collin P, Kaukinen K, Kurppa K, M\u00e4ki M. Validation of morphometric analyses of small-intestinal biopsy readouts in celiac disease. PLoS One. 2013 Oct 11;8(10):e76163.<\/p>\n\n\n\n<p>Taavela J, Viiri K, Popp A, Oittinen M, Dotsenko V, Per\u00e4aho M, Staff S, Sarin J, Leon F, M\u00e4ki M, Isola J. Histological, immunohistochemical and mRNA gene expression responses in coeliac disease patients challenged with gluten using PAXgene fixed paraffin-embedded duodenal biopsies. BMC Gastroenterol. 2019 Nov 15;19(1):189.<\/p>\n\n\n\n<p>Taavela J et al. Apolipoprotein A4 Defines the Villus-Crypt Border in Duodenal Specimens for Celiac Disease Morphometry. Front Immunol. 2021 Jul 29;12:713854. doi: 10.3389\/fimmu.2021.713854. eCollection 2021.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Jilab Inc. has a modern histopathology laboratory, which is specialized in providing services for academic research and for pharma industry. Jilab offers histotechnical services, including tissue processing, sectioning, staining, immunohistochemistry, whole slide imaging, quantitative image analysis and reporting. Additionally, Jilab offers RNA extraction and RNAseq services. The laboratory is run by Prof. Jorma Isola, (MD, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-290","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/jilab.fi\/index.php\/wp-json\/wp\/v2\/pages\/290","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jilab.fi\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/jilab.fi\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/jilab.fi\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jilab.fi\/index.php\/wp-json\/wp\/v2\/comments?post=290"}],"version-history":[{"count":23,"href":"https:\/\/jilab.fi\/index.php\/wp-json\/wp\/v2\/pages\/290\/revisions"}],"predecessor-version":[{"id":962,"href":"https:\/\/jilab.fi\/index.php\/wp-json\/wp\/v2\/pages\/290\/revisions\/962"}],"wp:attachment":[{"href":"https:\/\/jilab.fi\/index.php\/wp-json\/wp\/v2\/media?parent=290"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}