Pathology Contract Services (celiac etc.)

Jilab Inc. has a modern histopathology laboratory, which is specialized in providing services for academic research and for pharma industry.

Jilab offers a large scale of histotechnical services, including tissue processing, sectioning, staining, virtual slide scanning imaging, quantitative analysis and reporting. Additionally, Jilab offers RNA extraction and RNAseq services. The laboratory is run by Prof. Jorma Isola, (MD, PhD), who is board-certified pathologist with 25 year experience in histopathology.

Together with Professor Markku Mäki, Jilab has recently specialized in quantitative morphometry of celiac disease, who has developed and validated quantitative moprhometric methods for analyzing duodenal villus atrophy, crypt hyperplasia, and inflammation. The methods are described in Taavela J et al. 2013.

Jilab laboratory is certified by an international quality assurance organisation (Bureau Veritas).

References:

Daveson A, Popp A, Taavela J, Goldstein K, Isola J, Truitt K, Mäki M, Anderson RP, on behalf of the RESET CeD Study Group. Baseline quantitative histology in therapeutics trials reveals villus atrophy in most patients with coeliac disease who appear well controlled on gluten‐free diet. GastroHep https://doi.org/10.1002/ygh2.380. First published: 17 November 2019

Taavela J, Viiri K, Popp A, Oittinen M, Dotsenko V, Peräaho M, Staff S, Sarin J, Leon F, Mäki M, Isola J. Histological, immunohistochemical and mRNA gene expression responses in coeliac disease patients challenged with gluten using PAXgene fixed paraffin-embedded duodenal biopsies. BMC Gastroenterol. 2019 Nov 15;19(1):189.

Dotsenko V, Oittinen M, Taavela J, Popp A, Peräaho M, Staff S, Sarin J, Leon F, Isola J, Mäki M, Viiri K. Genome-wide transcriptomic analysis of intestinal mucosa in celiac disease patients on a gluten-free diet and post gluten challenge. Cell Mol Gastroenterol Hepatol. Epub 2020 July 31.

Lähdeaho ML, Scheinin M, Vuotikka P, Taavela J, Popp A, Laukkarinen J, Koffert J, Koivurova OP, Pesu M, Kivelä L, Lovró Z, Keisala J, Isola J, Parnes JR, Leon F, Mäki M. Safety and efficacy of AMG 714 in adults with coeliac disease exposed to gluten challenge: a phase 2a, randomised, double-blind, placebo-controlled study. Lancet Gastroenterol Hepatol. 2019 Dec;4(12):948-959. Epub 2019 Sep 4.

Cellier C, Bouma G, van Gils T, Khater S, Malamut G, Crespo L, Collin P, Green PHR, Crowe SE, Tsuji W, Butz E, Cerf-Bensussan N, Macintyre E, Parnes JR, Leon F, Hermine O, Mulder CJ; RCD-II Study Group Investigators. Safety and efficacy of AMG 714 in patients with type 2 refractory coeliac disease: a phase 2a, randomised, double-blind, placebo-controlled, parallel-group study. Lancet Gastroenterol Hepatol. 2019 Dec;4(12):960-970. doi: 10.1016/S2468-1253(19)30265-1. Epub 2019 Sep 4.PMID: 31494097

Repo M, Hannula M, Taavela J, Hyttinen J, Isola J, Hiltunen P, Popp A, Kaukinen K, Kurppa K, Lindfors K. Iron Transporter Protein Expressions in Children with Celiac Disease. Nutrients. 2021 Feb 27;13(3):776. doi: 10.3390/nu13030776.PMID: 33673530

Popp A, Taavela J, Graziano P, Parente P, Covelli C, Lamacchia C, Andriulli A, Mäki M, Isola J. A New Intraepithelial γδ T-Lymphocyte Marker for Celiac Disease Classification in Formalin-Fixed Paraffin-Embedded (FFPE) Duodenal Biopsies. Dig Dis Sci. 2020 Nov 3. doi: 10.1007/s10620-020-06680-x. Online ahead of print.PMID: 33140183

Schuppan D, Mäki M, Lundin KEA, Isola J, Friesing-Sosnik T, Taavela J, Popp A, Koskenpato J, Langhorst J, Hovde Ø, Lähdeaho ML, Fusco S, Schumann M, Török HP, Kupcinskas J, Zopf Y, Lohse AW, Scheinin M, Kull K, Biedermann L, Byrnes V, Stallmach A, Jahnsen J, Zeitz J, Mohrbacher R, Greinwald R; CEC-3 Trial Group. A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease. N Engl J Med. 2021 Jul 1;385(1):35-45. doi: 10.1056/NEJMoa2032441. PMID: 34192430

Taavela J, Viiri K, Välimäki A, Sarin J, Salonoja K, Mäki M, Isola J. Apolipoprotein A4 defines the villus-crypt border in duodenal specimens for celiac disease morphometry. Frontiers in Immunology 2021 (in press).

 

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